Seidal T, Karakostova P
Värmlands laboratorium för klinisk patologi och cytologi, Centralsjukhuset, Karlstad.
Lakartidningen. 2000 Feb 23;97(8):826-8.
A study is focused on the evaluation and comparison of the Bethesda ASCUS-diagnosis (Atypical Squamous Cells of Undetermined Significance) with the CIN I-classification (cervical intraepithelial neoplasia). From 1996 to 1999 2070 cases were reported as being ASCUS, which represented 2.5 per cent of 81,518 gynecological cases diagnosed during the same period. In 479 cases (23 per cent) a subsequent biopsy and/or endocervical curettage was performed. The control group was 740 (24 procent) of 3113 cases with CIN I diagnosis. Out of these two groups only those cases were selected that had undergone biopsy after either ASCUS diagnosis (135 cases) or CIN I diagnosis (740 cases). Out of the 135 ASCUS cases 25 (19 per cent) showed condylomata, 39 (29 per cent) cervical intraepithelial neoplasia (CIN I) and 20 (14 per cent) CIN II-III. No case of carcinoma was detected after histological examination. The control group of 740 cases included 102 (14 per cent) with condylomata, 208 (28 per cent) with CIN I and 118 (16 per cent) with CIN II-III. Among patients with an ASCUS diagnosis after cytology and subsequent cervical biopsy 43 per cent had cervical intraepithelial neoplasia, either CIN I or CIN II-III, as against 44 per cent in the control group. These findings indicate that ASCUS cytologically defines a group of patients with or at risk for developing of a squamous intraepithelial lesion.
一项研究聚焦于对贝塞斯达非典型鳞状细胞意义不明确诊断（ASCUS）与宫颈上皮内瘤变1级（CIN I）分类进行评估和比较。1996年至1999年期间，有2070例被报告为ASCUS，占同期诊断的81518例妇科病例的2.5%。其中479例（23%）随后进行了活检和/或宫颈管刮除术。对照组为3113例CIN I诊断病例中的740例（24%）。从这两组中仅选取那些在ASCUS诊断（135例）或CIN I诊断（740例）后接受了活检的病例。在135例ASCUS病例中，25例（19%）显示湿疣，39例（29%）为宫颈上皮内瘤变（CIN I），20例（14%）为CIN II - III。组织学检查后未检测到癌病例。740例的对照组中，102例（14%）有湿疣，208例（28%）有CIN I，118例（16%）有CIN II - III。在细胞学诊断为ASCUS并随后进行宫颈活检的患者中，43%患有宫颈上皮内瘤变，即CIN I或CIN II - III，而对照组为44%。这些发现表明，ASCUS在细胞学上定义了一组患有或有发展为鳞状上皮内病变风险的患者。
