Schäfer D, Molck H
MMW Munch Med Wochenschr. 1979 Mar 16;121(11):393-6.
Results of Trial in General Practice: Semi-Euglucon was tested in a field study by 366 general practitioners in a total of 2037 adult diabetics. The patient collective included primarily first stabilizations (56.5%), i. e. diabetics not previously treated with drugs, then transfers from sulfonyl ureas of the tolbutamide type (26.0%) and from biguanides (17.5%). During the trial period there was a significant improvement in the metabolic condition. The mean daily dose was 1.3 tablets Semi-Euglucon, small differences occurred depending on the nature of the previous treatment. After changing from the sulfonyl ureas glibornuride, glisoxepide or gliquidone the same mean daily dosage of 1.5 tablets/day was required as with the sulfonyl ureas mentioned--with considerable improvement in the metabolism.
366名全科医生在一项现场研究中对2037名成年糖尿病患者使用了半优降糖进行测试。患者群体主要包括首次病情稳定的患者(56.5%),即此前未接受药物治疗的糖尿病患者,其次是从甲苯磺丁脲类磺酰脲类药物(26.0%)和双胍类药物转换过来的患者(17.5%)。在试验期间,代谢状况有显著改善。半优降糖的平均日剂量为1.3片,根据先前治疗的性质存在细微差异。从格列波脲、格列吡嗪或格列喹酮等磺酰脲类药物转换后,所需的平均日剂量与上述磺酰脲类药物相同,为1.5片/天,且代谢有相当大的改善。