Ni D, Du M, Xu C
PUMC Hospital, Beijing.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1997 Oct;32(5):264-7.
The changes of the cross-sectional areas of anteroventral cochlear nucleus (AVCN) and posteroventral cochlear nucleus (PVCN) were studied in neonatal and adult guinea pigs after monaural cochlear ablation with computer imaging analysis system. The cross-sectional areas of neurons in AVCN and PVCN were not significantly changed after 24 h of monaural cochlear ablation in neonatal guinea pigs. But the cell areas of AVCN neurons of ablated side were respectively reduced by 20.93%, 25.70% and 28.72% compared to non-ablated side in 4 d, 7 d, 60 d after cochlear ablation, the cell areas of PVCN neurons were reduced by 17.58%, 20.30% and 38.55% respectively. The area reduction of AVCN and PVCN neurons of ablated side in 60 d group with monaural cochlear ablation were 51.00% and 32.75% relative to normal control group. Our results showed that cochlear ablation could results in rapid cell area reduction of VCN neurons in guinea pigs. Our investigation implied that it is important to stimulate the auditory nerve early in the patients with hearing loss.
采用计算机图像分析系统，研究新生和成年豚鼠单耳耳蜗切除术后腹侧前耳蜗核（AVCN）和腹侧后耳蜗核（PVCN）横截面积的变化。新生豚鼠单耳耳蜗切除24小时后，AVCN和PVCN中神经元的横截面积无明显变化。但在耳蜗切除后4天、7天、60天时，切除侧AVCN神经元的细胞面积与未切除侧相比分别减少了20.93%、25.70%和28.72%，PVCN神经元的细胞面积分别减少了17.58%、20.30%和38.55%。单耳耳蜗切除60天组切除侧AVCN和PVCN神经元的面积相对于正常对照组分别减少了51.00%和32.75%。我们的结果表明，耳蜗切除可导致豚鼠VCN神经元细胞面积迅速减少。我们的研究表明，对于听力损失患者，早期刺激听神经很重要。
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