Luo Z P, Zhang L, Turner R T, An K N
Orthopedic Biomechanics Laboratory, Mayo Clinic/Mayo Foundation, Rochester, MN 55905, USA.
IEEE Trans Biomed Eng. 2000 Mar;47(3):344-51. doi: 10.1109/10.827295.
A theoretical model was developed on the basis of fuzzy decision to predict cancellous bone structure following changes in mechanical stress/strain and estrogen. The model was validated experimentally by simulation of the normal structure of a rat distal femur, and further used to predict the structural alterations following ovarian hormone deficiency. The results show that net bone resorption after ovariectomy occurs in the metaphysis at locations where trabecula were subjected to the lowest mechanical stress/strain. These findings, consistent with experimental results, suggest that estrogen deficiency increase the mechanostat set point at which bone cells perceive mechanical stress/strain. Additionally, the results show that changes in bone architecture which are due to alterations in bone remodeling can be simulated by fuzzy decision without precise mathematical description, and multiple factors can also be readily incorporated into the model.
基于模糊决策建立了一个理论模型，以预测机械应力/应变和雌激素变化后松质骨结构的变化。通过模拟大鼠股骨远端的正常结构对该模型进行了实验验证，并进一步用于预测卵巢激素缺乏后的结构改变。结果表明，卵巢切除术后的净骨吸收发生在干骺端小梁承受最低机械应力/应变的部位。这些与实验结果一致的发现表明，雌激素缺乏会增加骨细胞感知机械应力/应变的机械调节设定点。此外，结果表明，无需精确的数学描述，通过模糊决策就可以模拟由于骨重塑改变而导致的骨结构变化，并且多个因素也可以很容易地纳入该模型。
