麻醉拮抗剂纳曲酮对果蝇生殖细胞致突变作用的证据。
Evidence for a mutagenic effect of the narcotic antagonist, naltrexone, in germ cells of Drosophila.
作者信息
Zimmering S
出版信息
Mutat Res. 1979 Feb;66(2):129-31. doi: 10.1016/0165-1218(79)90056-9.
PMID:107446
Abstract
The narcotic antagonist, Naltrexone, was tested for mutagenicity in Drosophila. The frequency of sex-linked recessive lethals at a non-toxic dose of 10 mg/ml was 0.43% (42 lethals in 9697 X-chromosomes tested) and 0.16% (19/11536) in the controls. The difference is statistically significant (P less than 0.001). Results from large-scale experiments testing for chromosome breakage and nondisjunction were negative.
摘要
对麻醉拮抗剂纳曲酮进行了果蝇致突变性测试。在10毫克/毫升的无毒剂量下，性连锁隐性致死率在测试的9697条X染色体中为0.43%（42个致死个体），而对照组为0.16%（19/11536）。差异具有统计学意义（P小于0.001）。关于染色体断裂和不分离的大规模实验结果为阴性。
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