Batiste-Alentorn M, Xamena N, Velázquez A, Creus A, Marcos R
Department de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Mutagenesis. 1986 Sep;1(5):343-6. doi: 10.1093/mutage/1.5.343.
The pyrethroid insecticide cypermethrin was tested for the induction of genetic damage in male germ cells of Drosophila melanogaster. Sex-linked recessive lethals, sex-chromosome loss and non-disjunction were studied following different routes of administration: adult feeding, injection and larval feeding. Our results show that, after adult injection and larval ingestion, cypermethrin induces a small but significant increase in the frequency of sex-linked recessive lethal mutations. However, no significant increases were observed in the frequency of sex chromosome loss or non-disjunction after exposure of male flies to cypermethrin at concentrations up to 20 p.p.m.
对拟除虫菊酯类杀虫剂氯氰菊酯进行了测试，以研究其对黑腹果蝇雄性生殖细胞的遗传损伤诱导作用。通过不同给药途径研究了性连锁隐性致死、性染色体丢失和不分离现象：成蝇喂食、注射和幼虫喂食。我们的结果表明，在成蝇注射和幼虫摄入氯氰菊酯后，性连锁隐性致死突变的频率有小幅但显著的增加。然而，当雄性果蝇暴露于浓度高达百万分之二十的氯氰菊酯时，性染色体丢失或不分离的频率并未观察到显著增加。
