Opletalová V, Sedivý D
Katedra farmaceutické chemie a kontroly léciv, Farmaceutické fakulty, Univerzity Karlovy, Hradec Králové.
Ceska Slov Farm. 1999 Nov;48(6):252-5.
Chalcones and their heterocyclic analogues show various biological effects, e.g. anti-inflammatory, antitumour, antibacterial, antituberculous, antiviral, antiprotozoal, gastroprotective, and others. The present review discusses in greater detail the fungistatic and fungicide properties of these compounds and presents also their chemical structures. The mechanism of antifungal effects of chalcones and their analogues has not been investigated in greater detail. Due to the presence of a reactive ketovinyl moiety in the molecule the compounds of this type are able to react with the thiol groups of enzymes. It cannot be excluded that chalcones interfere with the normal function of the membranes of fungi and moulds. Further investigation of chemical, physical, and biological properties of chalcones and their analogues could lead to the elucidation of the mechanism of their action and finding of effective fungicidal and fungistatic agents in this group of organic substances.
查耳酮及其杂环类似物具有多种生物学效应，如抗炎、抗肿瘤、抗菌、抗结核、抗病毒、抗原虫、胃保护等。本综述更详细地讨论了这些化合物的抑菌和杀菌特性，并介绍了它们的化学结构。查耳酮及其类似物的抗真菌作用机制尚未得到更深入的研究。由于该类分子中存在反应性酮乙烯基部分，这类化合物能够与酶的巯基发生反应。不能排除查耳酮会干扰真菌和霉菌膜的正常功能。进一步研究查耳酮及其类似物的化学、物理和生物学性质，可能会阐明其作用机制，并在这组有机物质中找到有效的杀菌和抑菌剂。
