Khoo B P, Tay Y K
National Skin Centre, Singapore.
Ann Acad Med Singap. 2000 Jan;29(1):105-7.
Lichen amyloidosus is a common skin disease seen among Asian patients.
Typical features range from macular hyperpigmentation to pruritic, lichenified, hyperpigmented papules. However, in this rare bullous variant of lichen amyloidosus, bullae and vesicles are present. Histopathologically, deposits of amyloid were seen in the papillary dermis, associated with an intraepidermal or subepidermal blister.
No good treatment so far, but pruritus can be relieved by topical steroid.
It is important to screen for systemic amyloidosis with the relevant investigations as it can present similarly with blistering eruptions, in which the prognosis would be grave.
淀粉样变苔藓是亚洲患者中常见的一种皮肤病。
典型特征从斑状色素沉着到瘙痒性、苔藓化、色素沉着丘疹不等。然而，在这种罕见的大疱性淀粉样变苔藓变体中，存在大疱和水疱。组织病理学上，在乳头真皮层可见淀粉样蛋白沉积，伴有表皮内或表皮下水疱。
目前尚无有效的治疗方法，但局部使用类固醇可缓解瘙痒。
通过相关检查筛查系统性淀粉样变很重要，因为它可能与水疱性皮疹表现相似，而后者预后严重。
