Orlova M E, Zakharov I S, Balaban P M
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2000 Jan-Feb;50(1):113-23.
It was shown earlier that some neurons in Helix CNS express the mRNA of the precursor of neuropeptide GFAD. Using the data obtained with the help of the whole-mount in situ hybridization, we tried to identify a group of such neurons, namely, the pedal caudo-ventral group and to determine their possible functions. The local extracellular stimulation of the pedal caudo-ventral group resulted in movements of reproductive organs in the semi-intact preparation and suppressed the activity of the modulatory neurons controlling feeding and defensive behavior. Application of synthetic peptide GFAD (10(-8) mol/l) also activated movements of the reproductive organs and suppressed the activity of the modulatory neuron controlling feeding behavior. Stimulation of the labial nerves resulted in suppression of caudo-ventral neurons with simultaneous activation of the modulatory neuron controlling feeding behavior. The obtained evidence suggests that the caudo-ventral neurons can regulate movements of the reproductive organs and also coordinate different functions in realization of the integral sexual behavior. This group of neurons inhibits the modulatory neurons controlling the forms of behavior incompatible with courtship, i.e., feeding and defensive forms.
先前的研究表明，螺旋神经中枢系统中的一些神经元表达神经肽GFAD前体的mRNA。利用全组织原位杂交获得的数据，我们试图识别出一组这样的神经元，即足尾腹侧组，并确定它们可能的功能。对足尾腹侧组进行局部细胞外刺激，在半完整标本中导致生殖器官运动，并抑制控制摄食和防御行为的调节神经元的活动。应用合成肽GFAD（10^(-8) mol/l）也能激活生殖器官的运动，并抑制控制摄食行为的调节神经元的活动。刺激唇神经会导致尾腹侧神经元受到抑制，同时激活控制摄食行为的调节神经元。所获得的证据表明，尾腹侧神经元可以调节生殖器官的运动，并且在整体性行为的实现中协调不同的功能。这组神经元抑制控制与求偶不相容的行为形式（即摄食和防御形式）的调节神经元。
