奥氮平治疗前后亨廷顿舞蹈病的脑单光子发射计算机断层扫描成像。病例报告。
Brain SPECT imaging in Huntington's disease before and after therapy with olanzapine. Case report.
作者信息
Etchebehere E C, Lima M C, Passos W, Maciel Júnior J A, Santos A O, Ramos C D, Camargo E E
机构信息
Department of Radiology, Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP), Brazil.
出版信息
Arq Neuropsiquiatr. 1999 Sep;57(3B):863-6. doi: 10.1590/s0004-282x1999000500021.
Olanzapine, an atypical antipsychotic drug, was administered to a patient with Huntington's disease (HD) with marked choreiform movements. Brain SPECT with 99mTc-HMPAO was performed before and after treatment. Brain SPECT imaging has been performed in patients with HD in order to determine the status of basal ganglia perfusion. The use of brain SPECT with 99mTc-HMPAO before and after treatment in patients with HD has not been yet reported. The marked hypoperfusion of the basal ganglia on brain SPECT performed before therapy with olanzapine improved significantly after treatment.
奥氮平是一种非典型抗精神病药物，被用于治疗一名患有显著舞蹈样动作的亨廷顿舞蹈症（HD）患者。在治疗前后进行了99mTc-HMPAO脑单光子发射计算机断层扫描（SPECT）。为了确定基底神经节灌注状态，已对HD患者进行了脑SPECT成像。HD患者在治疗前后使用99mTc-HMPAO脑SPECT的情况尚未见报道。在使用奥氮平治疗前进行的脑SPECT显示基底神经节明显灌注不足，治疗后有显著改善。
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