Osadchiĭ O E, Pokrovskiĭ V M
Kuban Medical Academy, Krasnodar.
Usp Fiziol Nauk. 2000 Jan-Mar;31(1):18-30.
In this review we analyse the experimental and clinical findings demonstrating important regulatory significance of met-enkephalin, leu-enkephalin and their derivatives in the control of cardiovascular system activity. Enkephalin-positive immunoreactivity is revealed in the heart of different species of animals, and their cardiovascular effects are established in numerous investigations. It is determined that cardiac effects of enkephalins are essentially associated with modulatory influence at the presynaptic and postsynaptic levels on the activity of extracardiac neural regulation. Cardiovascular effects of endogenous opioid system are extremely important in developing of myocardial ischemia, cardiac arrhythmias and congestive heart failure. The cellular mechanisms of opioid effects are associated with stimulation of mu- and delta-subtypes of opiate receptors which stimulation of mu- and delta-subtypes of opiate receptors which are coupled with conductivity of ion channels, adenylate cyclase activity, phosphoinositide turnover and calcium-calmodulin-dependent protein kynases.
在本综述中，我们分析了实验和临床研究结果，这些结果表明甲硫氨酸脑啡肽、亮氨酸脑啡肽及其衍生物在心血管系统活动控制中具有重要的调节意义。在不同种类动物的心脏中发现了脑啡肽阳性免疫反应，并且在众多研究中确定了它们的心血管效应。已确定脑啡肽的心脏效应主要与对心外神经调节活动的突触前和突触后水平的调节作用有关。内源性阿片系统的心血管效应在心肌缺血、心律失常和充血性心力衰竭的发生发展中极为重要。阿片类药物作用的细胞机制与刺激阿片受体的μ和δ亚型有关，这些亚型与离子通道传导性、腺苷酸环化酶活性、磷酸肌醇代谢和钙调蛋白依赖性蛋白激酶相关。
