Kishima M O, Barbisan L F, Estevão D, Rodrigues M A, Viana de Camargo J L
Departamento de Patologia Aplicada, Legislação e Deontologia, Faculdade de Medicina, UEL, Londrina, PR, Brazil.
Cancer Lett. 2000 Apr 28;152(1):37-44. doi: 10.1016/s0304-3835(99)00432-2.
The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S-transferase placental form (GST-P(+)) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P(+) foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide.
在一项大鼠肝脏中期致癌生物测定中，评估了饮食能量限制与低剂量杀菌剂六氯苯（HCB）之间的相互作用。给雄性Wistar大鼠喂食对照饮食或50%能量限制饮食，两种饮食均添加或不添加50 ppm的HCB，持续6周。单独接触HCB或进行能量限制对肝细胞谷胱甘肽S-转移酶胎盘形式（GST-P(+)）灶的发展没有任何影响。同时接触HCB和进行能量限制会导致肝小叶中央肥大和GST-P(+)灶发展显著增加。我们的研究结果表明，能量限制会增加肝脏对低剂量HCB的反应，揭示这种杀菌剂的促癌潜力。
