老年帕金森病的初始症状。

Initial symptoms of Parkinson's disease with elderly onset.

作者信息

Nagayama H, Hamamoto M, Nito C, Takagi S, Miyazaki T, Katayama Y

机构信息

Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan.

出版信息

Gerontology. 2000 May-Jun;46(3):129-32. doi: 10.1159/000022147.

DOI:10.1159/000022147

PMID:10754369

Abstract

BACKGROUND/OBJECTIVE: As the incidence of Parkinson's disease (PD) is related to aging, we consider it important to determine how the initial symptoms change with age in order to diagnose early elderly cases of PD accurately.

METHODS

84 patients (age at onset 70.7+/-9.0 years; mean +/-1 SD) were studied to see whether the initial symptoms change according to age.

RESULTS

The prevalence of resting tremor was significantly lower in patients of advanced age (p = 0.041). In contrast, the incidence of postural and gait disorders increased significantly with aging (p = 0.032). The prevalences of rigidity and kinetic disorders, which are important clinical features of PD, were not influenced by aging.

CONCLUSION

These findings suggest that the cause of PD is not related to the aging process itself, since the prevalences of all symptoms were not influenced by aging. Knowledge of the prevalence of the initial symptoms of PD may contribute to the accurate diagnosis in early and elderly cases.

摘要

背景/目的：由于帕金森病（PD）的发病率与衰老有关，我们认为确定初始症状如何随年龄变化对于准确诊断老年早期PD病例很重要。