Begić D, Hotujac L, Jokić-Begić N
Department of Psychiatry, KBC Rebro, Zagreb, Croatia.
Neuropsychobiology. 2000;41(3):166-70. doi: 10.1159/000026650.
The aim of the study was to determine the possible differences in quantitative EEG parameters of schizophrenic patients before and during therapy with neuroleptics. First EEG recordings were obtained from schizophrenic patients (n = 50) who had not been taking any medicaments during the preceding 2 months. Second EEG recordings were obtained during the administration of neuroleptic therapy. Amplitude values of particular spectral segment, i.e. delta, theta, alpha 1, alpha 2, beta 1 and beta 2 (after fast Fourier transformation) were analyzed. The F3, F4, C3, C4, T3, T4, P3, P4, O1 and O2 regions were observed. The effect of pharmacotherapy manifested as a decrease in delta and beta 2 activities. The alterations of the delta spectrum were recorded in each patient subgroup (regardless of the neuroleptic used). The changes in beta 2 activity were registered in patients on haloperidol and fluphenazine.
该研究的目的是确定精神分裂症患者在使用抗精神病药物治疗前和治疗期间定量脑电图参数的可能差异。首先，从50名精神分裂症患者身上获取脑电图记录，这些患者在之前的2个月内未服用任何药物。第二次脑电图记录是在抗精神病药物治疗期间获得的。分析了特定频谱段（即δ波、θ波、α1波、α2波、β1波和β2波，经快速傅里叶变换后）的振幅值。观察了F3、F4、C3、C4、T3、T4、P3、P4、O1和O2区域。药物治疗的效果表现为δ波和β2波活动减少。在每个患者亚组中均记录到了δ波频谱的改变（无论使用何种抗精神病药物）。在使用氟哌啶醇和氟奋乃静的患者中记录到了β2波活动的变化。
