Ailioaie C, Lupuşoru-Ailioaie L M
Second Paediatric Clinic, Faculty of Medicine, Gr. T. Popa University of Medicine and Pharmacy, Iassy.
Rev Med Chir Soc Med Nat Iasi. 1997 Jul-Dec;101(3-4):134-8.
The main goal of the present study was to investigate comparatively (in the last 8 years) the effects of nonsteroidal antiinflammatory drugs (NSAIDs) on a sample of 100 children diagnosed with juvenile chronic arthritis (JCA). The patients were divided in 3 smaller groups, as follows: group 1--prescribed diclofenac, group 2--paduden and group 3--aspirin. Clinical features and laboratory findings were evaluated after: a 2 months trial, 4 months trial, 6 months trial, 2 years trial, 3 years trial and more than 5 years trial, from the beginning of the NSAIDs therapy. The results were the followings: within the first 12 weeks of therapy with NSAIDs a good response was obtained in 64% (group 1), 59% (group 2) and 53% (group 3) of the managed children, respectively; after 8 years of treatment for the children remained under medical observation in our clinic, the remission was obtained in 68% (diclofenac), 60% (paduden) and 64% (aspirin) of the patients on NSAIDs therapy. The incidence of side-effects in the groups treated with diclofenac and paduden has been present in a smaller percentage and less severe than in the aspirin's group. No child managed with diclofenac had major gastrointestinal, hepatic or renal reactions. These results highlight the superiority of diclofenac as a new drug over aspirin and paduden, in the treatment of JCA.
本研究的主要目的是比较（过去8年）非甾体抗炎药（NSAIDs）对100名被诊断为幼年慢性关节炎（JCA）的儿童样本的影响。患者被分为3个较小的组，如下：第1组——服用双氯芬酸，第2组——服用帕度德，第3组——服用阿司匹林。从NSAIDs治疗开始后，在2个月试验、4个月试验、6个月试验、2年试验、3年试验和超过5年试验后评估临床特征和实验室检查结果。结果如下：在NSAIDs治疗的前12周内，分别有64%（第1组）、59%（第2组）和53%（第3组）的接受治疗儿童获得了良好反应；在我们诊所接受医学观察的儿童经过8年治疗后，接受NSAIDs治疗的患者中分别有68%（双氯芬酸）、60%（帕度德）和64%（阿司匹林）获得缓解。双氯芬酸和帕度德治疗组的副作用发生率比阿司匹林组的百分比更低且症状更轻。服用双氯芬酸治疗的儿童没有出现严重的胃肠道、肝脏或肾脏反应。这些结果突出了双氯芬酸作为一种新药在治疗JCA方面优于阿司匹林和帕度德。
