Teleman S, Mihailovici M S, Hilgarth M, Freudenberg N, Bettendorf H
Disciplina de Morfopatologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1999 Jul-Dec;103(3-4):131-5.
This study investigated the p53 positivity correlated with the receptor status, in different grades and stages of endometrial carcinoma.
The study included 88 endometrioid-type carcinomas and 5 non-endometrioid-type carcinomas. Paraffin sections were used for the ordinary histological diagnosis and for immunohistochemical diagnosis by avidin-biotin-peroxidase technique.
p53 positivity was identified in 10 endometrioid-type carcinomas (11.4%) and 3 non-endometrioid type carcinomas (60%). Most of the p53 positive cases were receptor negative and observed in advanced stages and histological grades. No associated endometrial hyperplasia was p53 positive, while a positive intraepithelial non-endometrioid carcinoma was identified.
p53 positivity is most frequently identified in non-endometrioid type, receptor negative adenocarcinomas, even in a precursor lesion as it is intraepithelial carcinoma, while in endometrioid, receptor positive carcinomas it appear in late stages of development, never being identified in precursor lesions.
本研究调查了p53阳性与不同分级和分期子宫内膜癌受体状态之间的相关性。
该研究纳入了88例子宫内膜样癌和5例非子宫内膜样癌。石蜡切片用于常规组织学诊断及采用抗生物素蛋白-生物素-过氧化物酶技术进行免疫组化诊断。
在10例子宫内膜样癌（11.4%）和3例非子宫内膜样癌（60%）中检测到p53阳性。大多数p53阳性病例为受体阴性，且见于晚期和高组织学分级。相关的子宫内膜增生均无p53阳性，但发现1例上皮内非子宫内膜样癌呈阳性。
p53阳性最常见于非子宫内膜样型、受体阴性的腺癌，即使在其上皮内癌这种前驱病变中也是如此；而在子宫内膜样、受体阳性的癌中，p53阳性出现在疾病发展的晚期，在前驱病变中从未检测到。
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