Mitchell P B
School of Psychiatry, University of New South Wales, Australia.
Br J Clin Pharmacol. 2000 Apr;49(4):303-12. doi: 10.1046/j.1365-2125.2000.00174.x.
Therapeutic drug monitoring (TDM) of a number of psychotropic medications has proven to be of value, enabling minimization of the limitations of considerable genetic variability in their metabolism and the high rates of poor compliance with many psychiatric disorders. Therapeutic ranges have been established for lithium, some of the tricyclic antidepressants, and clozapine. TDM has also been shown to be useful in avoiding toxicity (as many psychotropics have narrow therapeutic indices), particularly that due to interactions with other compounds.
对多种精神药物进行治疗药物监测（TDM）已被证明是有价值的，它能够将这些药物代谢过程中显著的基因变异性所带来的局限性以及许多精神疾病中高比例的依从性差问题降至最低。锂盐、一些三环类抗抑郁药和氯氮平已确定了治疗范围。TDM还被证明有助于避免毒性（因为许多精神药物的治疗指数较窄），尤其是避免因与其他化合物相互作用而导致的毒性。
