Rothrock J F, Mendizabal J E
University of South Alabama Headache Center, Mobile, Alabama 36617, USA.
Headache. 2000 Jan;40(1):17-9. doi: 10.1046/j.1526-4610.2000.00002.x.
To determine whether successful short-term prophylactic treatment of transformed migraine may be followed by a continued respite from headaches once the treatment has been discontinued ("carry-over effect").
The optimal duration of prophylactic treatment for pervasive headache and for migraine, in particular, is unknown.
We prospectively evaluated a series of patients with transformed migraine, all of whom were managed according to a uniform treatment protocol involving prophylactic therapy with divalproex sodium for a period not exceeding 12 weeks. All patients reporting a positive treatment response were followed for at least 2 months after the discontinuation of divalproex sodium, and the incidence of the carry-over effect in that group was assessed.
A short-term carry-over effect occurred in 12 (60%) of 20 patients, but more sustained relief occurred in only 8 (40%).
The successful short-term treatment of transformed migraine with divalproex sodium will often produce a short-term carry-over effect, but this response will be sustained only in a minority of patients.
确定转化型偏头痛的短期预防性治疗成功后，一旦治疗停止，头痛是否会持续缓解（“延续效应”）。
广泛性头痛尤其是偏头痛的最佳预防性治疗时长尚不清楚。
我们前瞻性评估了一系列转化型偏头痛患者，所有患者均按照统一治疗方案进行管理，该方案包括使用双丙戊酸钠进行不超过12周的预防性治疗。所有报告治疗反应阳性的患者在停用双丙戊酸钠后至少随访2个月，并评估该组中延续效应的发生率。
20例患者中有12例（60%）出现短期延续效应，但仅有8例（40%）获得更持久的缓解。
双丙戊酸钠成功短期治疗转化型偏头痛通常会产生短期延续效应，但只有少数患者的这种反应会持续。
