Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross C A, Takahashi H
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.
Ann Neurol. 2000 Apr;47(4):521-3.
Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.
α-突触核蛋白被认为在帕金森病（PD）中起重要作用。α-突触核蛋白基因突变是家族性帕金森病的病因，而α-突触核蛋白是散发性帕金森病患者路易小体的主要成分。Synphilin-1是一种新发现的蛋白质，我们之前发现它在体内与α-突触核蛋白相关联。我们现在发现Synphilin-1存在于帕金森病患者的路易小体中。我们的数据表明，Synphilin-1可能在路易小体形成及帕金森病发病机制中发挥作用。
