Yamaguchi Y
The Burnham Institute, La Jolla, California 92037, USA.
Cell Mol Life Sci. 2000 Feb;57(2):276-89. doi: 10.1007/PL00000690.
Lecticans are a family of chondroitin sulfate proteoglycans, encompassing aggrecan, versican, neurocan and brevican. These proteoglycans are characterized by the presence of a hyaluronan-binding domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular matrix molecules. In adult brain, lecticans are thought to interact with hyaluronan and tenascin-R to form a ternary complex. We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'.
凝集素是硫酸软骨素蛋白聚糖家族,包括聚集蛋白聚糖、多功能蛋白聚糖、神经蛋白聚糖和短蛋白聚糖。这些蛋白聚糖的特征是其核心蛋白中存在透明质酸结合结构域和C型凝集素结构域。通过这些结构域,凝集素与细胞外基质中的碳水化合物和蛋白质配体相互作用,并作为这些细胞外基质分子的连接物。在成人大脑中,凝集素被认为与透明质酸和腱生蛋白-R相互作用形成三元复合物。我们提出,透明质酸-凝集素-腱生蛋白-R复合物构成了成人大脑细胞外基质的核心组件,主要以“神经元周围网”的形式存在于神经元的细胞周隙中。