Auer Sophia, Schicht Martin, Hoffmann Lucas, Budday Silvia, Frischknecht Renato, Blümcke Ingmar, Paulsen Friedrich
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Partner of the European Reference Network (ERN) EpiCARE, 91054 Erlangen, Germany.
Cells. 2025 Feb 20;14(5):321. doi: 10.3390/cells14050321.
Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize the current state of knowledge about PNNs, their molecular composition and structure, as well as their functional roles and involvement in neurological diseases. Furthermore, future directions in PNN research are proposed, and the therapeutic potential of targeting PNNs to develop novel treatment options for various neurological disorders is explored. This review emphasizes the importance of PNNs in CNS physiology and pathology and underscores the need for further research in this area.
神经周网（PNNs）是一种特殊的细胞外基质结构，主要围绕中枢神经系统（CNS）中的抑制性神经元。它们已被确定为突触可塑性和神经元兴奋性的关键调节因子。这篇文献综述旨在总结关于神经周网的当前知识状态、其分子组成和结构，以及它们的功能作用和在神经系统疾病中的参与情况。此外，还提出了神经周网研究的未来方向，并探讨了靶向神经周网以开发各种神经系统疾病新治疗方案的治疗潜力。这篇综述强调了神经周网在中枢神经系统生理学和病理学中的重要性，并强调了该领域进一步研究的必要性。
