Conde R, Zamudio F Z, Rodríguez M H, Possani L D
Department of Molecular Recognition and Structural Biology, Institute of Biotechnology, National Autonomous University of Mexico, Avenida Universidad, 2001, P.O. Box 510-3, Cuernavaca, Mexico.
FEBS Lett. 2000 Apr 14;471(2-3):165-8. doi: 10.1016/s0014-5793(00)01384-3.
A novel peptide, scorpine, was isolated from the venom of the scorpion Pandinus imperator, with anti-bacterial activity and a potent inhibitory effect on the ookinete (ED(50) 0.7 microM) and gamete (ED(50) 10 microM) stages of Plasmodium berghei development. It has 75 amino acids, three disulfide bridges with a molecular mass of 8350 Da. Scorpine has a unique amino acid sequence, similar only to some cecropins in its N-terminal segment and to some defensins in its C-terminal region. Its gene was cloned from a cDNA library.
一种名为蝎毒素的新型肽，是从帝王蝎毒液中分离出来的，它具有抗菌活性，对伯氏疟原虫发育的动合子阶段（半数有效剂量为0.7微摩尔）和配子阶段（半数有效剂量为10微摩尔）有强大的抑制作用。它有75个氨基酸，三个二硫键，分子量为8350道尔顿。蝎毒素有独特的氨基酸序列，仅在其N端片段与某些天蚕素相似，在C端区域与某些防御素相似。它的基因是从一个cDNA文库中克隆出来的。
