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对感染的免疫反应及其在感染性休克中的作用。

Immunologic response to infection and its role in septic shock.

作者信息

Casey L C

机构信息

Department of Medicine, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.

出版信息

Crit Care Clin. 2000 Apr;16(2):193-213. doi: 10.1016/s0749-0704(05)70107-x.

DOI:10.1016/s0749-0704(05)70107-x
PMID:10768079
Abstract

In summary, the invasion of bacteria across mucosal surfaces is met with a vigorous host response that includes complement, antibody formation (thymus-independent and eventually thymus-dependent), phagocytosis, production of antibacterial peptides and proteins, the production of cytokines that result in activation of phagocytes and endothelial cells to attract more phagocytes, and the formation of fibrin to limit the spread of infection. The best summary of immune response to infection was written by Lewis Thomas in 1974.

摘要

总之，细菌穿越黏膜表面的入侵会引发强烈的宿主反应，包括补体、抗体形成（非胸腺依赖性，最终为胸腺依赖性）、吞噬作用、抗菌肽和蛋白质的产生、细胞因子的产生，这些细胞因子会激活吞噬细胞和内皮细胞以吸引更多吞噬细胞，以及形成纤维蛋白以限制感染扩散。对感染的免疫反应的最佳总结是由刘易斯·托马斯在1974年撰写的。

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