Solid-phase synthesis of beta-lactams via the ester enolate-imine condensation route.
作者信息
Schunk S, Enders D
机构信息
Institut für Organische Chemie, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany.
出版信息
Org Lett. 2000 Apr 6;2(7):907-10. doi: 10.1021/ol0055465.
PMID:10768183
Abstract
The ester enolate-imine condensation route to beta-lactams via an immobilized ester enolate has been achieved for the first time. The key reaction in the synthesis is the cyclization of the resin bound ester dianion and an imine. Traceless cleavage from the T1-triazene linker system yields the desired beta-lactams.
摘要
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