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3-（2,4-二氯苯氧基）-1-（4-甲氧基苄基）-4-（4-硝基苯基）氮杂环丁烷-2-酮

3-(2,4-Di-chloro-phen-oxy)-1-(4-meth-oxy-benz-yl)-4-(4-nitro-phen-yl)azetidin-2-one.

作者信息

Atioğlu Zeliha, Akkurt Mehmet, Jarrahpour Aliasghar, Heiran Roghayeh, Ozdemir Namık

机构信息

Ilke Education and Health Foundation, Cappadocia Vocational College, The Medical Imaging Techniques Program, 50420 Mustafapaşa, Ürgüp, Nevşehir, Turkey.

Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2014 Jul 2;70(Pt 8):o835-6. doi: 10.1107/S1600536814015013. eCollection 2014 Aug 1.

DOI:10.1107/S1600536814015013
PMID:25249889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4158542/
Abstract

The β-lactam ring of the title compound, C23H18Cl2N2O5, is nearly planar [maximum deviation = 0.019 (2) Å for the N atom] and its mean plane makes dihedral angles of 56.86 (15), 68.83 (15) and 83.75 (15)° with the di-chloro-, nitro- and meth-oxy-substituted benzene rings, respectively. In the crystal, mol-ecules are linked by pairs of C-H⋯O hydrogen bonds, forming inversion dimers with R 2 (2)(10) loops. The dimers are linked by further C-H⋯O hydrogen bonds, forming sheets lying parallel to (001). The mol-ecular packing is further stabilized by C-H⋯π inter-actions.

摘要

标题化合物C23H18Cl2N2O5的β-内酰胺环接近平面结构（N原子的最大偏差为0.019 (2) Å），其平均平面与二氯、硝基和甲氧基取代的苯环分别形成56.86 (15)°、68.83 (15)°和83.75 (15)°的二面角。在晶体中，分子通过成对的C—H⋯O氢键相连，形成具有R 2 (2)(10)环的反演二聚体。这些二聚体通过进一步的C—H⋯O氢键相连，形成平行于(001)的片层。分子堆积通过C—H⋯π相互作用进一步稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6740/4158542/7f35d42b2605/e-70-0o835-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6740/4158542/7921b9d2db11/e-70-0o835-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6740/4158542/7f35d42b2605/e-70-0o835-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6740/4158542/7921b9d2db11/e-70-0o835-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6740/4158542/7f35d42b2605/e-70-0o835-fig2.jpg

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本文引用的文献

1
Chemical synthesis of β-lactams: asymmetric catalysis and other recent advances.β-内酰胺的化学合成：不对称催化及其他最新进展
Chem Rev. 2014 Aug 27;114(16):7930-53. doi: 10.1021/cr4005549. Epub 2014 Feb 20.
2
The chemistry and biological potential of azetidin-2-ones.氮杂环丁烷-2-酮的化学性质和生物学潜力。
Eur J Med Chem. 2014 Mar 3;74:619-56. doi: 10.1016/j.ejmech.2014.01.002. Epub 2014 Jan 10.
3
3-(4-Chloro-phen-oxy)-1-(4-meth-oxy-phen-yl)-4-(4-nitro-phen-yl)azetidin-2-one.3-（4-氯苯氧基）-1-（4-甲氧基苯基）-4-（4-硝基苯基）氮杂环丁烷-2-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1101-2. doi: 10.1107/S1600536811013018. Epub 2011 Apr 13.
4
3-(2,4-Dichloro-phen-oxy)-1-(4-meth-oxy-phen-yl)-4-(3-nitro-phen-yl)azetidin-2-one.3-（2,4-二氯苯氧基）-1-（4-甲氧基苯基）-4-（3-硝基苯基）氮杂环丁烷-2-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 18;67(Pt 1):o183. doi: 10.1107/S1600536810052645.
5
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
6
Advances in the catalytic, asymmetric synthesis of beta-lactams.
Acc Chem Res. 2004 Aug;37(8):592-600. doi: 10.1021/ar030055g.
7
An efficient, stereoselective solid-phase synthesis of beta-lactams using Mukaiyama's salt for the Staudinger reaction.
J Comb Chem. 2003 May-Jun;5(3):208-10. doi: 10.1021/cc020107d.
8
Stereoselective synthesis of beta-lactams with polyaromatic imines: entry to new and novel anticancer agents.含多芳族亚胺的β-内酰胺的立体选择性合成：通向新型抗癌剂之路。
J Med Chem. 2003 Jan 2;46(1):12-5. doi: 10.1021/jm0255825.
9
Enantioselective Staudinger synthesis of beta-lactams catalyzed by a planar-chiral nucleophile.平面手性亲核试剂催化的β-内酰胺对映选择性施陶丁格合成。
J Am Chem Soc. 2002 Feb 27;124(8):1578-9. doi: 10.1021/ja012427r.
10
Solid-phase synthesis of beta-lactams via the ester enolate-imine condensation route.
Org Lett. 2000 Apr 6;2(7):907-10. doi: 10.1021/ol0055465.