金黄色葡萄球菌在上皮细胞中诱导的细胞凋亡利用了一种涉及半胱天冬酶8和3的机制。
Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3.
作者信息
Wesson C A, Deringer J, Liou L E, Bayles K W, Bohach G A, Trumble W R
机构信息
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
出版信息
Infect Immun. 2000 May;68(5):2998-3001. doi: 10.1128/IAI.68.5.2998-3001.2000.
Abstract
In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.
摘要
在本研究中，我们证明了金黄色葡萄球菌诱导牛乳腺上皮（MAC-T）细胞凋亡的机制涉及半胱天冬酶8和3，这是导致细胞凋亡的蛋白水解级联反应的两个关键组分。此外，内化的金黄色葡萄球菌可诱导MAC-T细胞表达炎性细胞因子肿瘤坏死因子α和白细胞介素-1β。这些数据表明，金黄色葡萄球菌的内化可能在体内诱导特定的细胞反应，最终可能影响感染进程。
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