冠状动脉钙化：来自心源性猝死受害者的见解。

Coronary calcification: insights from sudden coronary death victims.

作者信息

Burke A P, Taylor A, Farb A, Malcom G T, Virmani R

机构信息

Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA.

出版信息

Z Kardiol. 2000;89 Suppl 2:49-53. doi: 10.1007/s003920070099.

DOI:10.1007/s003920070099

PMID:10769403

Abstract

We studied 108 cases of sudden coronary death at autopsy. Any calcification was present in 55% of men and women under 40 years; all hearts showed some calcification by age 50 in men, and by age 60 in women. The only risk factor independently associated with increased calcification was diabetes mellitus, in women only. The degree of calcification was greatest for acute and healed plaque ruptures, and the least for plaque erosion. Calcification in coronary atherosclerosis appears to be delayed in women, is greatest in women diabetics, and is associated with one type of plaque instability, namely plaque rupture.

摘要

我们对108例心脏解剖的冠状动脉猝死病例进行了研究。40岁以下男性和女性中，55%存在钙化；男性50岁时所有心脏均显示有一定程度的钙化，女性60岁时所有心脏均显示有一定程度的钙化。唯一与钙化增加独立相关的危险因素是糖尿病，且仅见于女性。急性和愈合的斑块破裂钙化程度最高，斑块侵蚀钙化程度最低。冠状动脉粥样硬化中的钙化在女性中似乎出现较晚，在女性糖尿病患者中最为严重，并且与一种斑块不稳定类型即斑块破裂有关。