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[颈动脉狭窄的自然史及手术指征]

[Natural history and indications for surgery in carotid stenosis].

作者信息

Schweiger H

机构信息

Abteilung für Gefässchirurgie, Herz- und Gefäss-Klinik Bad Neustadt.

出版信息

Zentralbl Chir. 2000;125(3):221-7.

Abstract

Atherosclerotic stenoses of the internal carotid artery are often the underlying cause for ischemic stroke. Several studies show a strong correlation between the grade of stenosis and stroke risk. When cerebral symptoms occur in patients with a carotid artery stenosis of 60% or more the risk of stroke within the following 12 months is over 10%. Large randomised studies show that patients with a high grade carotid artery stenosis benefit clearly from carotid endarterectomy. Surgical treatment reduces stroke risk by more than 70% in these patients. Symptomatic patients with stenoses less than 40% do not benefit by endarterectomy even when surgical complication rate is low. The benefit of carotid endarterectomy is proven for asymptomatic stenoses, too. In asymptomatic patients, however, an operative procedure is justified only when surgical complication rate is 3% or less.

摘要

颈内动脉粥样硬化狭窄通常是缺血性中风的潜在病因。多项研究表明狭窄程度与中风风险之间存在密切关联。当颈动脉狭窄60%或以上的患者出现脑部症状时,在接下来的12个月内中风风险超过10%。大型随机研究表明,重度颈动脉狭窄患者明显受益于颈动脉内膜切除术。手术治疗可使这些患者的中风风险降低70%以上。狭窄程度小于40%的有症状患者即使手术并发症发生率较低,也无法从内膜切除术中获益。颈动脉内膜切除术对无症状狭窄患者也已被证实有效。然而,对于无症状患者,只有当手术并发症发生率为3%或更低时,手术才是合理的。

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