Viktorov V V, Viktorova T V, Mironov P I, Khustnutdinova E K
Anesteziol Reanimatol. 2000 Jan-Feb(1):32-4.
In order to elucidate the contribution of hereditary factor (dose of ribosome genes) to the realization of organ dysfunction syndromes in children with surgical infection, the total size of silver nitrate-stained nucleoli-forming regions (Ag-NFR) of acrocentric chromosomes in karyotypes was assessed in 22 patients aged from 14 months to 12 years, 17 of these with appendicular peritonitis, 4 with destructive pneumonia, and 1 with acute hematogenic osteomyelitis. Pyoseptic diseases involved no organ dysfunction in 10 patients, and in 12, multiple organ dysfunction was diagnosed. Our findings indicate that the carriers of low-copy variants of ribosome genes are characterized by hereditary predisposition to lowered individual resistance of the organism. Therefore, children with surgical infection with a decreased size of Ag-NFR (low dose of ribosome genes) in the karyotype potentially represent a group at risk of multiple organ dysfunction realization.
为了阐明遗传因素（核糖体基因剂量）对手术感染患儿器官功能障碍综合征发生的影响，我们评估了22例年龄在14个月至12岁之间患儿核型中近端着丝粒染色体经硝酸银染色的核仁形成区（Ag-NFR）的总面积。其中17例患有阑尾腹膜炎，4例患有坏死性肺炎，1例患有急性血源性骨髓炎。10例患儿的脓毒症未累及器官功能障碍，12例被诊断为多器官功能障碍。我们的研究结果表明，核糖体基因低拷贝变异的携带者具有机体个体抵抗力降低的遗传易感性。因此，核型中Ag-NFR面积减小（核糖体基因剂量低）的手术感染患儿可能是发生多器官功能障碍的高危人群。
