Kato M, Miyakawa M, Okada K
Department of Urology, Satitama Medical School, Japan.
Anticancer Res. 2000 Jan-Feb;20(1C):641-3.
Several pathways for immunodepression induced by stress and injury have been speculated, with precise analysis regarding out correlations between sympathetic nerve system and immunodepressive cytokines. Here, we show an interesting case and a clinical study of psychological disorders of urological advanced cancer patients. In the case report, a male renal-cell cancer patient whose disease disappeared following interferon therapy is presented whose disease relapsed five years after therapy and eight months after a traffic injury. Careful observation of the history suggests that severe pain could destruct patient's own anti-cancer mechanisms. In the clinical study on psychological disorders of the 131 patients, a higher rate (28%) of disorders was recognised in renal-cell cancer patients than in other cancer patients. Serum CRP values of the renal-cell cancer patients with the disorders was significantly higher than those of the same cancer patients without the disorders. A complicated inter-relationship between the central nercous system, various external forces, the cancer itself and the immune system may exist and have an influence on the efficacy of biotherapy.
人们推测了由压力和损伤引起免疫抑制的几种途径，对交感神经系统与免疫抑制细胞因子之间的相关性进行了精确分析。在此，我们展示了一个有趣的病例以及对泌尿外科晚期癌症患者心理障碍的临床研究。在病例报告中，呈现了一名男性肾细胞癌患者，其疾病在干扰素治疗后消失，但在治疗五年后且在发生交通伤八个月后疾病复发。对病史的仔细观察表明，剧痛可能破坏患者自身的抗癌机制。在对131名患者心理障碍的临床研究中，肾细胞癌患者中被认可的障碍发生率（28%）高于其他癌症患者。有障碍的肾细胞癌患者的血清CRP值显著高于无障碍的同一癌症患者。中枢神经系统、各种外力、癌症本身和免疫系统之间可能存在复杂的相互关系，并对生物治疗的疗效产生影响。
