Suginoshita T, Kusuzaki K, Nagaoka T, Murata H, Hirata M, Hashiguchi S, Hirasawa Y
Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan.
Anticancer Res. 2000 Jan-Feb;20(1B):511-4.
We encountered a very rare case that suggested the natural development of osteosarcoma from a precancerous lesion. The patient presented with a huge osteosarcoma in the distal femur on the initial consultation to our hospital. He had undergone X-ray examination twice previously, due to a knee injury. The findings of the lesion detected by the first X-ray examination were similar to a fibrous cortical defect (FCD), differing from those of an osteosarcoma lesion detected by second and last X-ray examinations. We retrospectively estimated the growth rate of the FCD-like and osteosarcoma lesions and found that FCD-like lesion was not osteosarcoma, but might have been a precancerous lesion. We also speculated that this osteosarcoma lesion might have appeared 18 months before the patient consulted our hospital.
我们遇到了一个非常罕见的病例，提示骨肉瘤可能由癌前病变自然发展而来。该患者首次到我院就诊时，表现为股骨远端巨大骨肉瘤。他此前因膝关节损伤曾接受过两次X线检查。第一次X线检查发现的病变表现类似于纤维皮质缺损（FCD），与第二次也是最后一次X线检查发现的骨肉瘤病变不同。我们回顾性评估了FCD样病变和骨肉瘤病变的生长速度，发现FCD样病变并非骨肉瘤，而可能是癌前病变。我们还推测，该骨肉瘤病变可能在患者到我院就诊前18个月就已出现。
