Dazzi C, Cariello A, Giannini M, Del Duca M, Giovanis P, Fiorentini G, Leoni M, Rosti G, Turci D, Tienghi A, Vertogen B, Zumaglini F, De Giorgi U, Marangolo M
Dipartimento di Oncologia ed Ematologia, Ospedale Santa Maria delle Croci, Ravenna, Italy.
Anticancer Res. 2000 Jan-Feb;20(1B):515-8.
The purpose of our study was to evaluate the activity and toxicity of a sequential chemo-radiotherapeutic treatment on the basis of an earlier report by The Johns Hopkins Oncology Center.
Eighteen patients with histologically diagnosed malignant gliomas entered the study. Fifteen patients had glioblastoma multiforme (83%). BCNU (40 mg/sqm/die) and Cisplatin (40 mg/sqm/die) were administered concurrently for 3 days every 3-4 weeks. Radiotherapy consisted of 45 Gy whole cranial irradiation plus a 15 Gy boost on the preoperative volume.
Thirteen patients had measurable disease and were evaluable for response. After chemotherapy we obtained 3 CRs (complete remission) and 4 PRs (partial remission) (RR (response rate 54%). Three PRs were converted to CRs after radiotherapy, for a complete remission rate of 46% (6/13). The median duration of response was 10 months. The median survival of the entire patients population was 9 months with 33% survival rates at 1 year. Hematological toxicity grade 4 in one patient and grade 3 in two patients were the major complications due to chemotherapy.
Our sequential chemo-radiotherapeutic regimen appears to have significant activity in adults with newly diagnosed high-grade gliomas.
我们研究的目的是在约翰霍普金斯肿瘤中心早期报告的基础上，评估序贯放化疗的活性和毒性。
18例经组织学诊断为恶性胶质瘤的患者进入本研究。15例为多形性胶质母细胞瘤（83%）。每3 - 4周同时给予卡氮芥（40mg/平方米/天）和顺铂（40mg/平方米/天），共3天。放疗包括全脑45Gy照射加术前靶区15Gy的推量照射。
13例患者有可测量的病灶，可评估疗效。化疗后获得3例完全缓解（CR）和4例部分缓解（PR）（缓解率54%）。放疗后3例PR转化为CR，完全缓解率为46%（6/13）。缓解的中位持续时间为10个月。全体患者的中位生存期为9个月，1年生存率为33%。化疗的主要并发症为1例4级血液学毒性和2例3级血液学毒性。
我们的序贯放化疗方案对新诊断的高级别胶质瘤成人患者似乎有显著活性。
