Tunçbilek E, Boduroğlu K, Alikaşifoğlu M
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1999 Jul-Sep;41(3):299-305.
The aim of the study was to determine the prevalence rate and risk factors relevant to neural tube defects (NTDs) in Turkey. All livebirths and stillbirths recorded at the university hospitals throughout Turkey between July 1993-June 1994 were evaluated with respect to congenital anomalies. For each birth, information was recorded about the child, the mother, the pregnancy and risk factors. A total of 66 cases with a NTD were recorded in 21,907 births. Prevalence rate of NTDs was 30.1 per 10,000 births. Of these 66 cases, 29 (43.9%) were male and 37 (56.1%) female. Female/male ratio was 1.27. The ratio of spina bifida/anencephaly is 1.20 for Turkey. Maternal illiteracy, maternal advanced age and residence in northern or eastern regions of Turkey are shown to be risk factors for having a baby with a NTD. The prevalence rate of NTDs is very high for Turkey. Geographical distribution of NTDs in this country confirms a relationship between the socioeconomic status and environmental factors for the development of a NTD. The results of this study point to the importance establishing a health policy to prevent neural tube defects in Turkey.
该研究的目的是确定土耳其神经管缺陷（NTDs）的患病率及相关风险因素。对1993年7月至1994年6月期间土耳其各大学医院记录的所有活产和死产进行先天性异常评估。对于每一例出生情况，均记录了有关婴儿、母亲、妊娠及风险因素的信息。在21,907例出生中，共记录到66例神经管缺陷病例。神经管缺陷的患病率为每10,000例出生中有30.1例。在这66例病例中，29例（43.9%）为男性，37例（56.1%）为女性。男女比例为1.27。土耳其脊柱裂/无脑儿的比例为1.20。母亲文盲、母亲高龄以及居住在土耳其北部或东部地区被证明是生出神经管缺陷患儿的风险因素。土耳其神经管缺陷的患病率非常高。该国神经管缺陷的地理分布证实了社会经济状况与神经管缺陷发生的环境因素之间的关系。本研究结果表明在土耳其制定预防神经管缺陷健康政策的重要性。
