Marubio L M, Changeux J
CNRS UA D1284-"Neurobiologie Moleculaire", Institut Pasteur, 28, rue du Dr. Roux, 75724, Paris, France.
Eur J Pharmacol. 2000 Mar 30;393(1-3):113-21. doi: 10.1016/s0014-2999(00)00007-8.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels, which are involved in a wide range of neuronal functions. During the past decade, a large number of nicotinic acetylcholine receptor subunits have been cloned and showed a discreet yet overlapping distribution pattern. Recently, several groups have produced mutant mice lacking specific nicotinic acetylcholine receptor subunits. In this review, we focus on how the study of these knockout mouse models has advanced our understanding of the role individual nicotinic acetylcholine receptor subunits play in the function and composition of endogenous receptors and the diverse pharmacological actions of nicotine in the mammalian nervous system.
烟碱型乙酰胆碱受体是五聚体配体门控离子通道，参与多种神经元功能。在过去十年中，大量烟碱型乙酰胆碱受体亚基已被克隆，并呈现出离散但重叠的分布模式。最近，几个研究小组培育出了缺乏特定烟碱型乙酰胆碱受体亚基的突变小鼠。在这篇综述中，我们重点关注对这些基因敲除小鼠模型的研究如何增进了我们对单个烟碱型乙酰胆碱受体亚基在体内受体的功能和组成中所起作用以及尼古丁在哺乳动物神经系统中多样药理作用的理解。
