Monteil A, Navarrot P, Kienlen J, DuCailar J
Ann Anesthesiol Fr. 1976;17(2):71-6.
Two cases of anaphylactic-type reaction to alfadione were referred to our Department for immuno-allergic enquiry. From the clinical standpoint, the pictures obtained were rather similar, dominated by dramatic collapse of abrupt onset associated with an erythemato-oedematous cervico-facial rash, however with a favourable course under respiratory and circulatory emergency resuscitation. The immunological enquiry carried out in both cases did not enable one to attribute the responsibility for the accident to alfadione or to cremophor EL nor to be able to put it down to a direct pharmacological histamine-liberation, or to a specific histamine-liberation due to an antigen-antibody reaction.
有两例对阿法双酮发生过敏样反应的病例被转至我科进行免疫过敏调查。从临床角度来看，所呈现的症状颇为相似，主要表现为突发的严重虚脱，并伴有颈面部红斑性水肿皮疹，不过在呼吸和循环系统紧急复苏的情况下病情转好。对这两例病例进行的免疫调查既无法将此次事故的责任归咎于阿法双酮或聚氧乙烯蓖麻油，也不能归结于直接的药理学组胺释放，或者因抗原抗体反应导致的特异性组胺释放。
