Kelly J K, Wade M J
Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66045, USA.
J Theor Biol. 2000 May 7;204(1):83-101. doi: 10.1006/jtbi.2000.2003.
Balancing selection at one locus can increase the amount of selectively neutral variation within neighboring genomic regions. Discrete phenotypic polymorphisms studied in natural populations are frequently determined by sets of interacting genes instead of alternative alleles at single loci. We extend coalescent theory to investigate balancing selection on combinations of linked genes. We find that variation at neutral sites is increased across a much larger genomic region relative to the single-locus models: the entire region lying between the two loci in balanced combination is affected to some degree. Epistatic selection maintains these high levels of neutral variation because it directly opposes the homogenizing effect of recombination. The results of the theory are discussed in relation to published gene sequence data, primarily from Drosophila.
一个基因座上的平衡选择可以增加相邻基因组区域内选择性中性变异的数量。在自然种群中研究的离散表型多态性通常由相互作用的基因集决定，而不是单个基因座上的替代等位基因。我们扩展了合并理论，以研究连锁基因组合上的平衡选择。我们发现，相对于单基因座模型，中性位点的变异在更大的基因组区域内增加：处于平衡组合的两个基因座之间的整个区域都受到一定程度的影响。上位性选择维持了这些高水平的中性变异，因为它直接对抗重组的同质化效应。结合已发表的主要来自果蝇的基因序列数据，对该理论的结果进行了讨论。
