用（99m）锝-甲氧基异丁基异腈/（201）铊双放射性核素显像评估小鼠肿瘤对紫杉醇的耐药性
Assessment of resistance to paclitaxel of murine tumors by (99m)Tc-MIBI/(201)Tl dual-radionuclide imaging.
作者信息
Oriuchi N, Jibu T, Milas L, Choe J, Kuang L, Kim E E, Hunter N R, Wallace S, Podoloff D A
机构信息
Departments of Department of Nuclear Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
出版信息
Nucl Med Biol. 2000 Feb;27(2):127-33. doi: 10.1016/s0969-8051(99)00099-2.
This study investigated P-glycoprotein (Pgp) expression by murine tumors with and without resistance to paclitaxel and the role of (99m)Tc-2-methoxyisobutylisonitrile (MIBI)/(201)Tl imaging in predicting the effect of paclitaxel. Antitumor effect of paclitaxel and biodistribution of the radiopharmaceuticals were evaluated in mice bearing four tumor types. Pgp expression did not correlate with the antitumor efficacy of paclitaxel. Although the absolute uptake of (99m)Tc-MIBI did not correlate with Pgp expression, (99m)Tc-MIBI could predict paclitaxel sensitivity by its higher uptake.
本研究调查了对紫杉醇有抗性和无抗性的小鼠肿瘤中P-糖蛋白（Pgp）的表达情况，以及（99m）锝-2-甲氧基异丁基异腈（MIBI）/（201）铊显像在预测紫杉醇疗效方面的作用。在携带四种肿瘤类型的小鼠中评估了紫杉醇的抗肿瘤效果和放射性药物的生物分布。Pgp表达与紫杉醇的抗肿瘤疗效无关。虽然（99m）Tc-MIBI的绝对摄取量与Pgp表达无关，但（99m）Tc-MIBI可通过其较高的摄取量预测紫杉醇敏感性。
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