Bhargava V K, Balakrishnan S
Department of Pharmacology, PIGIMER, Chandigarh.
Indian J Physiol Pharmacol. 1999 Jul;43(3):373-7.
The role of nitric oxide (NO) on acute hypoglycemia-induced seizures in mice was investigated using insulin as the hypoglycemic agent. The NO precursor L-arginine in the doses of 150, 500 and 750 mg/kg exhibited a dose-dependent protective effect against seizures induced by 8 mu/kg insulin. The NO synthase inhibitor (L-NMMA) at the doses of 50 and 100 mg/kg potentiated the subconvulsive doses of insulin (2 mu/kg). The onset, duration, number of seizures and the mortality were noted in a 2 hr study period. The results of this study suggest than NO plays an important protective role in acute hypoglycemia induced seizures which are known to occur through the activation of NMDA receptors.
以胰岛素作为降血糖剂，研究了一氧化氮（NO）在小鼠急性低血糖诱导癫痫发作中的作用。150、500和750mg/kg剂量的NO前体L-精氨酸对8μg/kg胰岛素诱导的癫痫发作表现出剂量依赖性保护作用。50和100mg/kg剂量的NO合酶抑制剂（L-NMMA）增强了胰岛素亚惊厥剂量（2μg/kg）的作用。在2小时的研究期内记录癫痫发作的起始、持续时间、发作次数和死亡率。本研究结果表明，NO在急性低血糖诱导的癫痫发作中起重要保护作用，已知这种癫痫发作是通过N-甲基-D-天冬氨酸（NMDA）受体的激活而发生的。
