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隐静脉动脉化能否预防严重下肢缺血患者的大截肢?一项对比研究。

Does saphenous vein arterialisation prevent major amputation in critical leg ischaemia? A comparative study.

作者信息

Mätzke S, Pitkänen J, Lepäntalo M

机构信息

Department of Surgery, Helsinki University Central Hospital, Finland.

出版信息

J Cardiovasc Surg (Torino). 1999 Dec;40(6):845-7.

Abstract

BACKGROUND

Arterialisation of the great saphenous vein has been suggested to improve distal circulation in patients with critical leg ischaemia not accessible for reconstructive surgery. As the technique has been a matter of controversy the aim was to assess the outcome of a series of own patients treated with arterialisation and compare them with conservatively treated patients.

EXPERIMENTAL DESIGN

a retrospective cohort study.

SETTING

an academic referral centre (Department of Surgery, Helsinki University Central Hospital) together with a district hospital (Peijas-Rekola Hospital).

PATIENTS AND INTERVENTIONS

14 consecutive patients with critical leg ischaemia treated with arterialisation of the great saphenous vein in the district hospital were compared with 14 age, sex, diabetes and symptom severity-matched controls with critical leg ischaemia treated conservatively in the academic referral centre.

MEASURES

major amputations and patient survival.

RESULTS

The leg salvage rate was 57% at one year in the arterialisation group and 54% in the conservative group (NS) but the survival rate at one year was 92% in the operative group and 64% in the control group (NS).

CONCLUSIONS

Arterialisation did not have any effect on leg salvage. The results of this study do not support the use of arterialisation as a treatment for critical leg ischaemia

摘要

背景

对于无法进行重建手术的严重下肢缺血患者,有人提出大隐静脉动脉化可改善远端循环。由于该技术一直存在争议,本研究旨在评估一系列接受动脉化治疗患者的治疗结果,并将其与接受保守治疗的患者进行比较。

实验设计

一项回顾性队列研究。

研究地点

一家学术转诊中心(赫尔辛基大学中心医院外科)和一家地区医院(佩亚斯 - 雷科拉医院)。

患者及干预措施

将地区医院连续14例接受大隐静脉动脉化治疗的严重下肢缺血患者,与学术转诊中心14例年龄、性别、糖尿病情况及症状严重程度相匹配的接受保守治疗的严重下肢缺血对照患者进行比较。

测量指标

大截肢率和患者生存率。

结果

动脉化组1年时的保肢率为57%,保守组为54%(无显著差异),但手术组1年生存率为92%,对照组为64%(无显著差异)。

结论

动脉化对保肢无任何影响。本研究结果不支持将动脉化作为严重下肢缺血的一种治疗方法

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