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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gavras H, Brunner H R, Laragh J H, Gavras I, Vukovich R A

Clin Sci Mol Med Suppl. 1975 Jun;2:57s-60s. doi: 10.1042/cs048057s.

The anti-hypertensive effect of converting enzyme inhibition was evaluated in twenty-three hypertensive patients (seven renovascular, four essential, four malignant, one scleroderma, three chronic renal failure, four primary or idiopathic aldosteronism). 2. In sixteen patients a single injection (1--4 mg/kg) of the inhibitor produced an immediate anti-hypertensive effect, which lasted up to 16 h. In six patients the anti-hypertensive effect of the inhibitor was significantly improved after sodium depletion. 3. Plasma renin activities increased and plasma aldosterone concentrations decreased consistently except in idiopathic aldosteronism. 4. Converting enzyme inhibition provides a direct way of defining the degree of renin-dependency of the hypertension. Accordingly, it can be used diagnostically and for planning appropriate therapy. Therapeutically, it could be advantageous in hypertensive emergencies because of its safety, specificity and capacity to reduce aldosterone secretion.

对23例高血压患者（7例肾血管性、4例原发性、4例恶性、1例硬皮病、3例慢性肾衰竭、4例原发性或特发性醛固酮增多症）评估了转换酶抑制的降压作用。2. 16例患者单次注射（1 - 4mg/kg）抑制剂产生了即刻降压作用，持续长达16小时。6例患者在钠缺失后抑制剂的降压作用显著增强。3. 除特发性醛固酮增多症外，血浆肾素活性升高而血浆醛固酮浓度持续降低。4. 转换酶抑制提供了一种直接界定高血压肾素依赖性程度的方法。因此，它可用于诊断并规划适当的治疗。在治疗方面，因其安全性、特异性及降低醛固酮分泌的能力，在高血压急症中可能具有优势。

Gavras H, Brunner H R, Laragh J H, Gavras I, Vukovich R A

Clin Sci Mol Med Suppl. 1975 Jun;2:57s-60s. doi: 10.1042/cs048057s.

The anti-hypertensive effect of converting enzyme inhibition was evaluated in twenty-three hypertensive patients (seven renovascular, four essential, four malignant, one scleroderma, three chronic renal failure, four primary or idiopathic aldosteronism). 2. In sixteen patients a single injection (1--4 mg/kg) of the inhibitor produced an immediate anti-hypertensive effect, which lasted up to 16 h. In six patients the anti-hypertensive effect of the inhibitor was significantly improved after sodium depletion. 3. Plasma renin activities increased and plasma aldosterone concentrations decreased consistently except in idiopathic aldosteronism. 4. Converting enzyme inhibition provides a direct way of defining the degree of renin-dependency of the hypertension. Accordingly, it can be used diagnostically and for planning appropriate therapy. Therapeutically, it could be advantageous in hypertensive emergencies because of its safety, specificity and capacity to reduce aldosterone secretion.

对23例高血压患者（7例肾血管性、4例原发性、4例恶性、1例硬皮病、3例慢性肾衰竭、4例原发性或特发性醛固酮增多症）评估了转换酶抑制的降压作用。2. 16例患者单次注射（1 - 4mg/kg）抑制剂产生了即刻降压作用，持续长达16小时。6例患者在钠缺失后抑制剂的降压作用显著增强。3. 除特发性醛固酮增多症外，血浆肾素活性升高而血浆醛固酮浓度持续降低。4. 转换酶抑制提供了一种直接界定高血压肾素依赖性程度的方法。因此，它可用于诊断并规划适当的治疗。在治疗方面，因其安全性、特异性及降低醛固酮分泌的能力，在高血压急症中可能具有优势。