哮喘患者与正常人血小板组胺和血清素及其相应血浆氧化酶的比较研究。

Comparative study of platelet histamine and serotonin with their corresponding plasma oxidases in asthmatics with normals.

作者信息

Matkar N M, Rupwate R U, Desai N K, Kamat S R

机构信息

Dept. of Pharmacology and Respiratory Medicine, KEM Hospital, Parel, Mumbai.

出版信息

J Assoc Physicians India. 1999 Sep;47(9):878-82.

PMID:10778656

Abstract

OBJECTIVE

Asthma is well controllable but non-curable disease. Exact pathophysiology involved is unresolved till today. Role of allergic hypersensitivity reaction in asthmatic on-set is well established. Present work is an effort to elucidate some basic points of unresolved pathophysiology of asthma taking platelets as marker.

MATERIAL AND METHODS

A group of 52 normal human subjects in the age group of 20-60 years were studied for platelet histamine and serotonin levels and also for their plasma metabolising enzymes diamine oxidase (DAO) and monoamine oxidase (MAO). The data was collected for 79 asthmatic patients at different stages of asthma and accordingly were studied as four different groups of seventy nine asthmatics those were on regular treatment and were comfortable with drugs and were free from symptomatic attack formed gr. I; these (79) patients were followed-up during their symptomatic phase (gr. II) and same (79) patients immediately after their recovery from symptomatic stage studied as gr. III members. All the 79 asthmatic patients fall in gr. I, II and III in a serial manner i.e. all (n = 79) in each group. A separate group of thirty seven patients with known history of asthma but were symptom free and also off drugs for last 2-4 years formed gr. IV.

RESULTS

Results showed mean platelet count in asthmatics at all four stages were in the normal range but were slightly low in comparison with normals. Both the enzymatic levels (DAO and MAO) in gr. I, II and III were significantly higher than normals but were same in the case of gr. IV patients. Low levels of platelet biogenic amines were observed in asthmatics (gr. I to gr. IV) than normals.

CONCLUSIONS

Thus, study parameters showed significant difference in asthmatics and normals. Findings of the study have been utilized to understand unanswered hypersensitivity shown by the asthmatics over normal individuals (non-asthmatics).

摘要

目的

哮喘是一种可有效控制但无法治愈的疾病。其确切的病理生理学机制至今尚未完全明确。过敏超敏反应在哮喘发病中的作用已得到充分证实。本研究旨在以血小板为标志物，阐明哮喘未解决的病理生理学的一些基本要点。

材料与方法

对一组52名年龄在20 - 60岁的正常人类受试者进行血小板组胺和血清素水平以及血浆代谢酶二胺氧化酶（DAO）和单胺氧化酶（MAO）的研究。收集了79名处于不同哮喘阶段的患者的数据，并将其分为四组进行研究，这79名哮喘患者正在接受常规治疗，对药物耐受且无症状发作，构成第一组；这些（79名）患者在症状期（第二组）接受随访，并且在从症状期恢复后立即进行研究，作为第三组成员。所有79名哮喘患者依次归入第一组、第二组和第三组，即每组均为79名。另外一组37名有哮喘病史但无症状且在过去2 - 4年未用药的患者构成第四组。