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副肿瘤性小脑变性与霍纳综合征:一名患霍奇金病儿童中两种罕见表现的关联

Paraneoplastic cerebellar degeneration and Horner syndrome: association of two uncommon findings in a child with Hodgkin disease.

作者信息

Emir S, Kutluk M T, Göğüş S, Büyükpamukçu M

机构信息

Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

出版信息

J Pediatr Hematol Oncol. 2000 Mar-Apr;22(2):158-61. doi: 10.1097/00043426-200003000-00015.

Abstract

An 11-year-old boy admitted with a right cervical mass was found to have Hodgkin disease. On admission, he also had right Homer syndrome and severe cerebellar ataxia. Cranial MRI revealed marked cerebellar atrophy. He was treated with chemotherapy consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), in addition to radiotherapy. Three months after initiation of therapy, he had a partial remission of tumor. Neurologic symptoms improved dramatically after chemotherapy started. Hodgkin disease should be included in the differential diagnosis of children with cerebellar findings and Horner syndrome.

摘要

一名因右侧颈部肿块入院的11岁男孩被诊断为霍奇金病。入院时,他还患有右侧霍纳综合征和严重的小脑共济失调。头颅磁共振成像显示明显的小脑萎缩。除放疗外,他接受了由多柔比星、博来霉素、长春花碱和达卡巴嗪(ABVD)组成的化疗。治疗开始三个月后,他的肿瘤部分缓解。化疗开始后,神经症状显著改善。对于有小脑症状和霍纳综合征的儿童,鉴别诊断应包括霍奇金病。

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