Tai C, Booth A M, Robinson C J, de Groat W C, Roppolo J R
Department of Pharmacology, University of Pittsburgh, PA 15261, USA. mijr+@pitt.edu
IEEE Trans Rehabil Eng. 2000 Mar;8(1):1-10. doi: 10.1109/86.830943.
During multimicroelectrode stimulation within the cat L6 spinal cord, the number of electrodes activated, their separation distance, and the stimulus interleave time all influenced isometric knee joint extension torque. The torque evoked by stimulation with a three electrode combination could be enhanced or suppressed when compared with that evoked by single or paired electrode stimulation. A similar difference was noted when comparing two electrode combination versus single electrode stimulation. Relative fatigue was not improved significantly by interleaving the stimuli from two or three microelectrodes. Compared with the extension torque response evoked by noninterleaved stimulation, torque evoked by interleaved stimulation with the two microelectrode combination was decreased when the electrode distance was 2.0 mm or less and increased when the electrode distance was 3.0 mm. Designing an optimal stimulation strategy for multimicroelectrode spinal cord stimulation will be challenging and complex if a suppression effect among these electrodes is to be avoided. To reduce muscle fatigue, an asynchronous, interleaved strategy of stimulation may be required.
在对猫的L6脊髓进行多微电极刺激期间，激活的电极数量、它们的间隔距离以及刺激交错时间都会影响等长膝关节伸展扭矩。与单电极或双电极刺激所诱发的扭矩相比，三电极组合刺激所诱发的扭矩可能会增强或受到抑制。在比较双电极组合刺激与单电极刺激时也发现了类似的差异。通过交错来自两个或三个微电极的刺激，相对疲劳并没有得到显著改善。与非交错刺激所诱发的伸展扭矩反应相比，当电极距离为2.0毫米或更小时，双电极组合交错刺激所诱发的扭矩会降低，而当电极距离为3.0毫米时则会增加。如果要避免这些电极之间的抑制作用，为多微电极脊髓刺激设计一种最佳刺激策略将具有挑战性且很复杂。为了减少肌肉疲劳，可能需要采用异步、交错的刺激策略。
