Hilbig H, Ernstberger J, Lenk C
Institute of Anatomy, University of Leipzig, Germany.
Exp Toxicol Pathol. 2000 Mar;52(1):23-5. doi: 10.1016/S0940-2993(00)80010-X.
A study about the distribution of neuronal nitric oxide synthase (n-NOS) and inducible NOS (i-NOS) was performed in microphthalmic retinas at postnatal day (pd) 2 and pd 7. Neither n-NOS nor i-NOS immunoresponse could be detected at pd 2. At pd 7, i-NOS activity was revealed in the retinas of mi/mi littermates but not in those of heterozygotes or wild-type littermates. The expression of n-NOS corresponded to the postnatal retinal development. Retinal rosettes were strongly labelled.
在出生后第2天（pd2）和第7天（pd7）对小眼畸形视网膜中神经元型一氧化氮合酶（n-NOS）和诱导型一氧化氮合酶（i-NOS）的分布进行了研究。在pd2时未检测到n-NOS和i-NOS免疫反应。在pd7时，i-NOS活性在纯合子（mi/mi）同窝仔鼠的视网膜中显示，但在杂合子或野生型同窝仔鼠的视网膜中未显示。n-NOS的表达与出生后视网膜发育相对应。视网膜玫瑰花结被强烈标记。
