Philippov P P
Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia.
Membr Cell Biol. 2000;13(2):195-206.
In the early 1970s it became clear that an unknown intracellular messenger participated in signal transduction in retinal rod cells. Ca2+ and cGMP had been considered as candidates for such a messenger until 1985 when the cGMP-gated conductance of the plasma membrane was discovered. However, for the last several years, Ca2+ has taken revenge as a signal molecule which contributed to the processes underlying the photoreceptor cell recovery. This review describes the overall picture of phototransduction molecular mechanisms with special emphasis on participation of Ca2+ in visual cell signalling.
20世纪70年代初，很明显有一种未知的细胞内信使参与视网膜视杆细胞的信号转导。在1985年发现质膜的cGMP门控电导之前，Ca2+和cGMP一直被认为是这种信使的候选者。然而，在过去的几年里，Ca2+作为一种信号分子进行了“报复”，它参与了光感受器细胞恢复的潜在过程。这篇综述描述了光转导分子机制的全貌，特别强调了Ca2+在视觉细胞信号传导中的作用。
