Forrester M B, Merz R D
Hawaii Birth Defects Program, Honolulu, Hawaii 96817-3533, USA.
Fetal Diagn Ther. 2000 May-Jun;15(3):146-51. doi: 10.1159/000020994.
To determine the influence of various factors on the prenatal diagnosis and elective termination of neural tube defects (NTDs) in Hawaii in 1986-1997.
Data from a birth defects registry were analyzed and included 245 cases.
74% of the cases were prenatally diagnosed and 48% were terminated. Anencephaly was more likely to be prenatally diagnosed and electively terminated than spina bifida or encephalocele. Other factors such as maternal age, race/ethnicity, place of residence, and elevated maternal serum alpha-fetoprotein influenced the prenatal diagnosis and/or elective termination of NTD-affected pregnancies. However, a given factor may influence prenatal diagnosis and elective termination in different ways.
Various diagnostic and demographic factors can influence the prenatal diagnosis and the subsequent termination of NTD-affected pregnancies.
确定1986 - 1997年间夏威夷各种因素对神经管缺陷（NTDs）产前诊断及选择性终止妊娠的影响。
对出生缺陷登记处的数据进行分析，纳入245例病例。
74%的病例进行了产前诊断，48%的病例终止妊娠。无脑儿比脊柱裂或脑膨出更有可能在产前被诊断并选择性终止妊娠。其他因素，如产妇年龄、种族/民族、居住地点以及孕妇血清甲胎蛋白升高，均会影响NTDs妊娠的产前诊断和/或选择性终止妊娠。然而，某一特定因素可能以不同方式影响产前诊断和选择性终止妊娠。
各种诊断和人口统计学因素会影响NTDs妊娠的产前诊断及随后的终止妊娠情况。
