Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors.
作者信息
Lübbers T, Angehrn P, Gmünder H, Herzig S, Kulhanek J
机构信息
Department of Infectious Diseases, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
出版信息
Bioorg Med Chem Lett. 2000 Apr 17;10(8):821-6. doi: 10.1016/s0960-894x(00)00109-8.
Abstract
We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity.
摘要
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