Wilk P J, Karipineni R C, Danese C A
Mount Sinai School of Medicine, City University of New York, NY 10029.
Angiology. 1976 Nov;27(11):611-4. doi: 10.1177/000331977602701101.
Biliary diversion in different ways has been studied as a prevention against induced hypercholesterolemia in experimental animals. A new model for the study of cholesterol metabolism is described in dogs in this paper. The technique consists in ligation and division of the common bile duct and interposition of an isoperistaltic loop of jejunum between the gallbladder and urinary bladder. This technique is free of complications such as diarrhea, infection, and peptic ulceration that are seen in other biliary diversion models, and it is tolerated well by the animals. This requires further study for its effectiveness in the prevention of experimental hypercholesterolemia and subsequent development of arteriosclerosis.
人们已经研究了以不同方式进行胆汁分流，作为预防实验动物诱发高胆固醇血症的方法。本文描述了一种在狗身上研究胆固醇代谢的新模型。该技术包括结扎和切断胆总管，并在胆囊和膀胱之间置入一段蠕动方向相同的空肠袢。该技术没有其他胆汁分流模型中出现的腹泻、感染和消化性溃疡等并发症，并且动物对其耐受性良好。其在预防实验性高胆固醇血症及随后的动脉粥样硬化发展方面的有效性需要进一步研究。
