Hauser J, Czarny M
Kliniki Psychiatrii Dorosłych AM w Poznaniu.
Psychiatr Pol. 1999 Jul-Aug;33(4):553-63.
The results of research concerning the importance of genetic factors in etiopathogenesis of affective diseases are presented. In molecular genetics research there are two most frequently applied strategies: searching of the whole genome in order to find new genes and molecular analysis of candidate genes. Candidate gene analysis consist in choosing a gene which could theoretically have a connection with the disease. The polymorphism of a chosen gene is estimated and then its connection with the disease is defined. The presented reference review concerns the results of candidate genes research, which refer to biochemical hypothesis of affective diseases. In many medical centers it was found that in affective disorders the polymorphism of gene's receptor D4, GABA and serotonin transporter could be of etiological importance.
本文介绍了有关遗传因素在情感性疾病病因学中重要性的研究结果。在分子遗传学研究中，有两种最常用的策略：对整个基因组进行搜索以寻找新基因，以及对候选基因进行分子分析。候选基因分析包括选择一个理论上可能与疾病有关的基因。对所选基因的多态性进行评估，然后确定其与疾病的关联。本文的参考文献综述涉及候选基因研究的结果，这些结果与情感性疾病的生化假说相关。在许多医学中心发现，在情感障碍中，基因受体D4、γ-氨基丁酸（GABA）和血清素转运体的多态性可能具有病因学意义。
