Joyner M V, Cassuto J P, Dujardin P, Barety M, Duplay H, Audoly P
Arch Dermatol. 1979 Mar;115(3):326-8.
Monoclonal gammopathies and other abnormalities of immunoglobulin production may characterize or frequently be associated with B-cell lymphoproliferative disorders. We describe a patient with a T-cell cutaneous lymphoma, expressed clinically as Sézary's syndrome, in association with an immunoglobulin A type kappa M-component monoclonal gammopathy. No evidence for the coincident presence of a malignant plasma dyscrasia was found. This clinical association may lend clinical support to the concept that Sézary's syndrome is a T-helper-cell malignant proliferation. A colonic carcinoma was also present, possibly representing a second manifestation of a functionally abnormal cellular immune system.
单克隆丙种球蛋白病和其他免疫球蛋白产生异常可能是B细胞淋巴增殖性疾病的特征或常与之相关。我们描述了一名患有T细胞皮肤淋巴瘤的患者，临床上表现为Sezary综合征，同时伴有免疫球蛋白A型κM成分单克隆丙种球蛋白病。未发现同时存在恶性浆细胞异常增生的证据。这种临床关联可能为Sezary综合征是T辅助细胞恶性增殖这一概念提供临床支持。患者还患有结肠癌，这可能代表了功能异常的细胞免疫系统的第二种表现形式。
